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2 080 873

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C1

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IPC

(21) (22)

Application

93057634/14, 1993-12-27

(22)

Actual filing date

1993-12-27

(45)

Published

1997-06-10

(72)

Inventor

Zagidullin N.V.Galeeva Eh.G.Kulagin V.F.Jusupov V.G.

(73)

Holder

Nauchno-Proizvodstvennoe Ob"Edinenie

METHOD OF HUMAN LEUKOCYTE INTERFERON PREPARING Russian patent published in 1997 - IPC

Abstract RU 2080873 C1

FIELD: medicinal industry. SUBSTANCE: leukocytes isolated from donor blood, leukocyte or erythrocyte mass were suspended in nutrient medium containing 0.0015 U/ml insulin and 1500-3000 IU/ml human leukocyte interferon and other necessary additions. Initial temperature of nutrient medium - 20 C, leukocyte amount - 10-20 mln/1 ml. Stimulation process is carried out by graduate increase of suspension temperature from 20 C to 36 C for 4-6 h. Then temperature is brought about to 35.9 35,9°C±0,1 0.1 C and induction of interferon biosynthesis is carried out. Antiviral activity of the obtained interferon is 10000-12000 IU/ml. EFFECT: increased yield of end product.

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RU 2 080 873 C1

Authors

Zagidullin N.V.

Galeeva Eh.G.

Kulagin V.F.

Jusupov V.G.

Dates

1997-06-10—Published

1993-12-27—Filed

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