PYRIMIDINE NUCLEOSIDE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND METHOD OF THEIR SYNTHESIS Russian patent published in 1997 - IPC

FIELD: organic chemistry. SUBSTANCE: product: derivatives of pyrimidine nucleoside of the general formula (I): where: R¹,R² and R³ are similar or different - H, alkanoyl-C₂-C₂₄, substituted alkanoyl-C₂-C₂₄ with at least one of A and/or B substituents given below or alkenylcarbonyl-C₃-C₂₄ at condition that at least one of R¹,R² and R³ - unsubstituted alkanoyl-C₅-C₂₄, indicated alkenylcarbonyl-C₃-C₂₄; one of R⁴ and R⁵ - H and other - cyano-group; indicated A substituent - hydroxy-, amino-group, protected amino-group, azido-, cyano-group, halogen atom; B substituent - C₁-C₈-aliphatic acylhydroxy-group, alkoxyalkoxy-group where each alkoxy-moiety has 1-6 carbon atoms, alkylthioalkoxy-group where alkyl moiety and alkoxy-moiety each has 1-6 carbon atoms, alkoxyalkoxyalkoxy-group where each alkoxy-moiety has 1-6 carbon atoms, aliphatic carboxy C₁-C₆-acylhydroxy-group, aliphatic carboxy C₁-C₆-acylthio-group, aralkyldithio-group where alkyl moiety has 1-4 carbon atoms, and aryl moiety means benzyl, alkylsulfonyl-group where alkyl moiety has 1-6 carbon, carbamoylhydroxy-group, or their pharmaceutically acceptable salts. Synthesized compounds were used as antitumor agents. EFFECT: improved method of synthesis. 10 cl, 24 dwg, 4 tbl