FIELD: organic chemistry. SUBSTANCE: product: compound of the formula (I) where: R1 - hydrogen, alkyl, cycloalkyl or alkanoyl; R2 - single bond, alkylene or alkylidene; R3 and R4 - each means hydrogen or alkyl; R6 - carboxyl or tetrazole-5-yl; X - oxygen or sulfur, and their pharmaceutically acceptable salts and esters that are antagonists of angiotensin-II and can be used for treatment and prophylaxis of hypertension and cardiovascular diseases. EFFECT: improved method of synthesis, enhanced effectiveness of treatment and prophylaxis. 21 cl, 2 tbl
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Authors
Dates
1997-08-10—Published
1993-06-01—Filed