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(19)

RU

(11)

2 090 615

(13)

C1

(51)

IPC

(21) (22)

Application

5011763/13, 1992-05-06

(22)

Actual filing date

1992-05-06

(45)

Published

1997-09-20

(72)

Inventor

Timoti Springer[Us]Robert Rotlejn[Us]Stiven Merlin[Us]Majkel Dastin[Us]

(73)

Holder

Dana Farber Kenzer Institjut

MONOCLONAL ANTIBODY R6-5-D6 INTERACTING WITH CELLULAR ADHESION ICAM-1 GLYCOPROTEIN DERIVATIVE Russian patent published in 1997 - IPC

Abstract RU 2090615 C1

FIELD: biotechnology, medicine. SUBSTANCE: invention relates to preparing monoclonal antibody R6-5-D6 that inhibits interaction of lymphocytes with glycoprotein of cellular adhesion ICAM-1. Antibodies were produced by murine hybridoma and belong to isotype Ig G2a. They can inhibit proliferation of mononuclear cells of human peripheral blood in systems depending on intercellular adhesion. Invention can be used in medicine for treatment of allergy, oncological diseases, in tissue transplantation. EFFECT: enhanced effectiveness of antibody. 4 dwg

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RU 2 090 615 C1

Authors

Timoti Springer[Us]

Robert Rotlejn[Us]

Stiven Merlin[Us]

Majkel Dastin[Us]

Dates

1997-09-20—Published

1992-05-06—Filed

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