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2 097 425

(13)

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IPC

(21) (22)

Application

94038730/13, 1994-10-12

(22)

Actual filing date

1994-10-12

(45)

Published

1997-11-27

(72)

Inventor

Ammosov A.D.Rukavishnikov M.Ju.Poryvaeva V.A.

(73)

Holder

Ammosov Aleksej DmitrievichRukavishnikov Mikhail Jur'EvichPoryvaeva Vera Aleksandrovna

STRAIN OF THE HYBRID CULTURED MAMMALIAN CELLS MUS MUSCULUS L - A PRODUCER OF MONOCLONAL ANTIBODIES TO A-DETERMINANT OF HEPATITIS B VIRUS SURFACE ANTIGEN Russian patent published in 1997 - IPC

Abstract RU 2097425 C1

FIELD: biotechnology, virology. SUBSTANCE: invention relates to preparing the strain of the hybrid cultured murine cells HBSV-3 producing monoclonal antibodies to a-determinant of hepatitis B virus surface antigen (HBSAg). Strain is obtained by hybridization of cells of myeloma P3-NS1-Ag4-1 with murine splenocytes of strain BALB/c immunized with hepatitis B virus surface antigen isolated from serum blood of patients with chronic hepatitis. The obtained strain produces monoclonal antibodies of class IgG1 interacting with conformational epitope on the group-specific a-determinant HBSAg and showing high stability. Monoclonal antibodies ensure to isolate HBSAg in solutions and biological fluids of organism. EFFECT: strain indicated above, enhanced effectiveness of the strain. 1 dwg

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RU 2 097 425 C1

Authors

Ammosov A.D.

Rukavishnikov M.Ju.

Poryvaeva V.A.

Dates

1997-11-27—Published

1994-10-12—Filed