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2 092 553

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IPC

(21) (22)

Application

94038719/13, 1994-10-12

(22)

Actual filing date

1994-10-12

(45)

Published

1997-10-10

(72)

Inventor

Ammosov A.D.Rukavishnikov M.Ju.Poryvaeva V.A.

(73)

Holder

Ammosov Aleksej DmitrievichRukavishnikov Mikhail Jur'EvichPoryvaeva Vera Aleksandrovna

STRAIN OF HYBRID CULTURED ANIMAL CELLS MUS MUSCULUS L - A PRODUCER OF MONOCLONAL ANTIBODIES RAISED TO A-DETERMINANT OF HEPATITIS B VIRUS SURFACE ANTIGEN Russian patent published in 1997 - IPC

Abstract RU 2092553 C1

FIELD: biotechnology, virology. SUBSTANCE: invention relates to preparing the strain of hybrid cultured murine cells HBSV-1 producing monoclonal antibodies raised to a-determinant of hepatitis B virus surface antigen (HBsAg). Strain is obtained by hybridization of myeloma P3-NS1-Ag4.1 cells with murine splenocytes (strain Balb/c) immunized with hepatitis B virus surface antigen isolated from blood serum of patients with chronic hepatitis. The obtained strain produces monoclonal antibodies of IgG1 class interacting with conformational epitope on the group-specific a-determinant HBsAg and showing high stability. The use of monoclonal antibodies ensures to detect HBsAg in solution and biological fluids of organism. EFFECT: cell strain indicated above, enhanced effectiveness of detection. 1 dwg

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RU 2 092 553 C1

Authors

Ammosov A.D.

Rukavishnikov M.Ju.

Poryvaeva V.A.

Dates

1997-10-10—Published

1994-10-12—Filed