FIELD: biotechnology, organic chemistry, biochemistry. SUBSTANCE: uniformly isotope-modified natural amino acids were prepared by incubation of strains - producers of the corresponding amino acid. Firstly, cells were grown on medium with glucose and acetate as carbon sources. Then cells were separated, washed out and used for preparing a suspension on the salt medium with a single carbon source as isotope-modified acetate as sodium acetate and/or ammonium acetate modified with isotopes $$$ or $$$ and/or $$$. New compounds modified with $$$ and $$$ were obtained first. EFFECT: improved method of preparing. 5 cl, 1 tbl
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