FIELD: organic chemistry. SUBSTANCE: invention describes compounds of the formula (I) 
where X - oxygen, chemical bond or NR5; Z - oxygen or sulfur. These compounds are inhibitors of lipoxygenase and useful as active agents in pharmaceutical compositions for treatment of inflammatory states in human and other mammalians caused by activity of lipoxygenase. EFFECT: improved method of synthesis. 16 cl, 1 tbl
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Year |
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Number |
| METHOD OF PREPARING N-HYDROXYUREA, N-HYDROXYUREA DERIVATIVES AND METHOD OF INHIBITING LIPOXYGENASE IN MAMMALS |
1991 |
- Takafumi Ikeda[Jp]
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|
RU2104267C1 |
| N-HYDROXYLUREAS AS ANTI-INFLAMMATORY AGENTS |
1995 |
- Ando Akemi
- Stivens Rodni V.
|
RU2152935C2 |
| DERIVATIVES OF ARYLSULFONYLAMINOHYDROXAMIC ACID, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION, METHOD OF INHIBITION OF MATRIX METALLOPROTEINASES AND METHOD OF PATIENT TREATMENT |
1996 |
- Ral'F P.Robinson
- Dzhejms P.Ritstsi
|
RU2145597C1 |
| DERIVATIVES OF ARYLSULFONYLHYDROXAMIC ACID |
1996 |
- Antoni D.Piskopio
- Dzhejms P.Rizzi
|
RU2146671C1 |
| 4-HETEROCYCLYL-SUBSTITUTED DERIVATIVE OF QUINAZOLINE, PHARMACEUTICAL COMPOSITION |
1995 |
|
RU2137762C1 |
| SUBSTITUTED PYRAZOLES, PHARMACEUTICAL COMPOSITION BASED ON SAID, METHOD OF PATIENT TREATMENT, INTERMEDIATE COMPOUND |
1993 |
- Dzhen M.Brajt
- Uillard M.Uehlch
|
RU2130453C1 |
| ARYLHYDROXYCYCLOALKENYL- AND ARYLHYDROXYIMINOCYCLOALKENYLHYDROXYUREAS AND PHARMACEUTICAL COMPOSITION INHIBITING ACTIVITY OF 5-LIPOXYGENASE |
1995 |
- Akiesi Kavai
- Makoto Kavai
- Rodni V.Stivens
|
RU2119479C1 |
| BENZOFUSED COMPOUNDS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, METHOD OF THEIR SYNTHESIS AND A METHOD OF SYNTHESIS OF AN INTERMEDIATE COMPOUND |
1992 |
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RU2114110C1 |
| BENZOPYRANE AND BENZOCONDENSED COMPOUNDS, INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITION AND A METHOD OF INHIBITION |
1995 |
- Mark A.Dombroski
- Kevin Kokh
- Ehntoni Daniehl' Piskop'O
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RU2128655C1 |
| PYRROLIDINYL DERIVATIVES OF HYDROXAMIC ACID, METHOD OF PREPARATION THEREOF, INTERMEDIATES, METHOD OF PREPARATION THEREOF (VERSIONS), METHOD OF TREATMENT |
1996 |
|
RU2144917C1 |
