METHOTREXATE DERIVATIVES, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION Russian patent published in 1998 - IPC

Abstract RU 2109016 C1

FIELD: organic chemistry. SUBSTANCE: invention proposes compound of the formula: $$$ where $$$ is $$$; $$$ is hydrogen atom, lower alkyl group containing 1-4 carbon atoms or benzyl group; n = 1-4 as a whole number; $$$ is $$$. This compound shows potential antirheumatic activity, carcinostatic property and low toxicity and can be used in medicine for psoriasis treatment. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 8 cl, 15 dwg

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RU 2 109 016 C1

Authors

Nobukhiro Okhi[Jp]

Khirokharu Matsuoka[Jp]

Katsukhito Mijamoto[Jp]

Khirosi Suzuki[Jp]

Nobuaki Kato[Jp]

Kejitiro Tsudzi[Jp]

Jasukhisa Takeda[Jp]

Masakhiko Mikhara[Jp]

Khiromiti Nisina[Jp]

Sin Simaoka[Jp]

Keniti Akamatsu[Jp]

Dates

1998-04-20Published

1991-08-14Filed