3-CYANOANDROSTA-3,5-DIENE-17BETA-CARBOXYLIC ACID AS INTERMEDIATE PRODUCT, AND METHOD OF PREPARING COMPOUNDS Russian patent published in 1998 - IPC

FIELD: medicine. SUBSTANCE: present invention describes 3-cyanoandrosta-3,5-diene-17β-carboxylic acid of formula given in the specification, used as intermediate product when preparing compounds of formula given in the specification wherein R¹ is hydrogen, C₁-C₆-alkyl substituted by at least one phenyl optionally having at least one substituent selected from substituents A; R² is substituted C₁-C₆ alkyl having at least one substituent selected from phenyl, furyl, thienyl or diphenylamino; in this case phenyl group is substituted by at least one substituent selected from substituents A. Substituents A are selected from alkyl C₁-C₆ groups, alkoxy C₁-C₆ groups, hydroxy groups, halogen atoms or dialkyl C₁-C₆ amino groups; R³ is carboxy group, and also pharmaceutically acceptable salts and esters thereof. Said compounds have useful 5α-reductase activity and are therefor e useful for treatment and prophylaxis of prostatic hypertrophy and in addition to other diseases disorders caused by higher levels of 5α-dihydrotestosteron. EFFECT: improved properties of the title compounds. 3 cl, 2 tbl