INDOLE DERIVATIVES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION SHOWING SELECTIVE BINDING ACTIVITY WITH RESPECT TO 5--HT RECEPTORS AND VASOCONSTRICTIVE EFFECT ASSOCIATED WITH 5-HT AGONISTIC EFFECT AND A METHOD OF SELECTIVE BINDING 5--HT RECEPTORS OR AGONISTIC EFFECT ON 5-HT RECEPTORS Russian patent published in 1998 - IPC

FIELD: organic chemistry and chemical technology, pharmacy. SUBSTANCE: product: compound of the formula (I) where R¹ and R² each means hydrogen or alkyl group; Z means ring taken from: (II) where n = 4, 5 or 6; (III) ; (IV) where R³ means hydrogen or alkyl group, and R⁴ means alkyl, methoxy, benzyl or R⁵ - NHCO-group where R⁵ means alkyl-group; (V) where R⁶ means alkyl-group, and its pharmaceutically acceptable salts that are benefit for treatment of patients with migraine and other disorders. These compounds are synthesized by decarboxylation of the corresponding indolyl-2-carboxylic acid. EFFECT: improved method of synthesis, enhanced effectiveness of compounds synthesized. 8 cl, 2 tbl, 2 ex