INDOLOPYRROLOCARBAZOLE DERIVATIVES AND METHODS OF PREPARATION THEREOF Russian patent published in 1998 - IPC

FIELD: medicine. SUBSTANCE: present invention describes indolopyrrolocarbazole of formula I: wherein R¹ and R² are each independently hydrogen, lower alkyl, lower alkenyl, phenyl, phenylalkyl, pyridyl or imidazolinyl, each of groups of lower alkyl, lower alkenyl, phenyl, phenylalkyl having optionally from 1 to 5 substituents selected from carboxy, carbamoyl, cyano and hydroxy; or y-R³ in which Y is carbonyl, thiocarbonyl or sulphonyl, and R³ is H, lower alkyl, trifluoromethyl, phenyl, lower alkoxy, hydrazino, amino, phenylamino, carbamoyl or pyridyl, lower alkyl or phenyl group having optionally from 1 to 4 substituents such as hydroxy, adjacent hydroxy groups protected by alkylene group, carboxy or cyano, or R¹ and R² taken together with nitrogen atom to which they are attached form piperazinyl or pyrrolidinyl, optionally hydroxyl substituted lower alkyl group, pentose or hexose group and independently hydrogen or halogen, OH, lower alkoxy or benzyloxy group. Compounds have excellent antitumor effect. EFFECT: improved properties of the title compounds. 9 cl, 3 tbl