METHOD FOR PRODUCTION OF LAPPACONITINE HYDROBROMIDE Russian patent published in 2007 - IPC A61K36/47 A61P9/06

Abstract RU 2295355 C2

FIELD: pharmaceutical industry, in particular method for production of lappaconitine hydrobromide.

SUBSTANCE: claimed method includes extraction of aconite grass with sulfuric acid aqueous solution at certain conditions; alkalization up to weak-acid reaction; alkaloid isolating with organic solvent; purification with activated carbon; chromatography on alumina; precipitation of lappaconitine base with acetone; and brominating in alcohol solution.

EFFECT: method of high yield; lappaconitine hydrobromide of improved purity.

5 cl, 4 ex

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RU 2 295 355 C2

Authors

Tuguntaev Gennadij Indzhitaevich

Dates

2007-03-20—Published

2004-09-17—Filed