TAXANE DERIVATIVE PHOSPHONOOXYMETHYL ESTERS, INTERMEDIATE COMPOUNDS, ANTITUMOR PHARMACEUTICAL COMPOSITION, METHOD OF TUMOR GROWTH SUPPRESSION IN MAMMALS Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to taxane derivative phosphonooxymethyl esters of the formula (I) where R¹ - hydroxy-group, -OCH₂(OCH₂)_mOP(O)(OH)₂ or OC(O)OR^x; R^2′ - hydrogen atom; R² - hydroxy-group, -OCH₂(OCH₂)_mO-P(O)(OH)_2′-OC(O)OR^x; or R^2′ - fluorine atom and R² - hydrogen atom; R³ - H, hydroxy-, acetoxy-group; R⁴,R⁵ is C_1-6-alkyl or Z-R⁶ where Z - a direct bond; R^6′ - aryl or heteroaryl; R^x is C_1-6-alkyl; p = 0 or 1; R⁶,R⁷ in common form oxo-group at condition that at least one of R¹,R² is OCH₂(OCH₂)_mOP(O)(OH)₂; m = 0 or 1, or their pharmaceutically acceptable salts that show antitumor activity. EFFECT: improved method of synthesis, antitumor activity of compounds. 54 cl, 5 tbl, 11 ex