ISOZERINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION, AND METHOD OF INHIBITION Russian patent published in 1999 - IPC

FIELD: pharmaceutical industry. SUBSTANCE: present invention describes isozerine derivatives of formula I: wherein Y is -CH=CH-; R₁ is hydrogen or halogen; R₂ is halogen, CH₃,OCH₃,NO₂ or CF₃, and n is 0-3, A is carboxy, or pharmaceutically acceptable nontoxic salts thereof, in vivo hydrolysable esters. Said derivatives are prepared by reacting compound II with compound III . Compounds of formula I show lenkotriene antagonistic activity. EFFECT: improved properties of the pharmaceutical composition. 9 cl, 24 ex, 2 tbl