DERIVATIVES OF 1-BIPHENYLMETHYLIMIDAZOLE, A METHOD OF THEIR SYNTHESIS AND A PHARMACEUTICAL COMPOSITION FOR TREATMENT AND PROPHYLAXIS OF PATIENTS WITH HYPERTENSION Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of 1-biphenylmethylimidazole of the formula (I) where means R¹-alkyl; C_1-6 and R² - hydrogen atom, R³-alkyl, C_1-6- -aryl; R⁴- - H or alkyl; R⁵ is COO-R^5a,, -CON-R⁸R⁹ where R⁸ and R⁹ - H, alkyl possibly substituted with carboxy- or alkoxycarbonyl-group; or R⁸ and R⁹ together form C_2-6-alkylene possibly substituted with alkoxycarbonyl; R^5a- means alkyl or alkanoylhydroxyalkyl, alkoxycarbonylhydroxyalkyl, (5-methyl- -2-oxo-1,3-dioxolene-4-yl)-methyl or phthalidyl; R⁶- is H; R⁷- means carboxyl or tetrazole-5-yl-group, or its pharmaceutically acceptable salts and esters which show hypotensive activity and can be used for treatment and prophylaxis of patients with hypertension, pathology of heart and circulation system. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 15 cl, 9 dwg, 7 tbl, 122 ex