1-BIPHENYLMETHYL IMIDAZOLE, PHARMACEUTICALLY ACCEPTABLE SALTS OR ETHERS THEREOF, AND METHOD OF PREPARATION THEREOF Russian patent published in 1997 - IPC

FIELD: pharmaceutical industry. SUBSTANCE: present invention describes compounds of formula (I): wherein R¹ is alkyl or alkenyl; R² and R³ are hydrogen, alkyl, alkenyl, cycloalkyl, aralkyl, aryl or aryl fused with cycloalkyl; R⁴ is hydrogen, alkyl, alkanoyl, alkenoyl, arylcarbonyl, alkoxycarbonyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahydrothienyl, tetrohydrofuryl, group of formula: SiR^aR^bR^c in which R^a, R^b and R^c are alkyl or aryl, alkoxymethyl, alkoxyalkoxy methyl, halo-alkoxy methyl, aralkyl, aryl or alkanoyloxymethoxy carbonyl; R⁵ is carboxy group or group of formula: -CONR⁸R⁹ in which R⁸ and R⁹ together form alkylene; R⁶ is hydrogen, alkyl, alkoxy or halogen; R⁷ is carboxy group or tetrazol-5-yl; or pharmaceutically acceptable salts and esters thereof have hypertensive activity and are useful for treatment and prophylaxis of hypertension. Compounds of the present invention are prepared by inter alia by reaction of a biphenylmethyl compound with imidazole compound. EFFECT: improved properties. 32 cl, 1 tbl