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2 129 276

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Application

95111751/14, 1995-07-06

(22)

Actual filing date

1995-07-06

(45)

Published

1999-04-20

(72)

Inventor

Mel'Nikova A.V.Zheleznikova G.F.Ivanova V.V.

(73)

Holder

Nauchno-Issledovatel'Skij Institut Detskikh Infektsij

METHOD OF RAPIDLY DETERMINING DIPHTHERIA IN CHILDREN Russian patent published in 1999 - IPC

Abstract RU 2129276 C1

FIELD: clinical immunology. SUBSTANCE: invention is developed for early diagnostics of diphtheria in children and immunologic monitoring in the course of treatment. Method consists in that diphtheria toxin is determined within circulating immune complexes. Heat-dissociated samples are applied then on test system with monoclonal antibodies to COOH-terminal region of toxin molecule and, when toxin level is 0.45 Lf/ml or higher, diphtheria is diagnosed. EFFECT: increased analytical specificity and sensitivity. 1 dwg, 2 tbl, 4 ex

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RU 2 129 276 C1

Authors

Mel'Nikova A.V.

Zheleznikova G.F.

Ivanova V.V.

Dates

1999-04-20—Published

1995-07-06—Filed

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