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IPC

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Application

97118009/13, 1997-10-31

(22)

Actual filing date

1997-10-31

(45)

Published

1998-11-27

(72)

Inventor

Dutov M.D.Khropov Ju.V.Kots A.Ja.Belushkina N.N.Busygina O.G.Severina I.S.Shevelev S.A.

(73)

Holder

Biologicheskij Fakul'Tet Mgu Im.M.V.Lomonosova

ACTIVATOR OF GUANYLATE CYCLASE SOLUBLE FORM Russian patent published in 1998 - IPC

Abstract RU 2122582 C1

FIELD: biochemistry. SUBSTANCE: invention proposes the use of 4,4-dihaloid-derivatives of 3,5-substituted pyrazole-1,2-dioxides of the general formula (I) as activating agents of guanylate cyclase soluble form. An activation degree if this enzyme for the proposed compounds is 280-500%. In part, for 3,5-diphenyl-4,4-dichloropyrazole-1,2-dioxide an activation degree is 380% (as compared with 250% for the known compound 3,5-diphenylpyrazole-4-one-1,2-dioxide). Invention can be used for study of regulation of guanylate cyclase soluble form. EFFECT: enhanced activating effect on enzyme, broadened pattern of specific regulators of this enzyme.

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RU 2 122 582 C1

Authors

Dutov M.D.

Khropov Ju.V.

Kots A.Ja.

Belushkina N.N.

Busygina O.G.

Severina I.S.

Shevelev S.A.

Dates

1998-11-27—Published

1997-10-31—Filed

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