FIELD: organic chemistry, biochemistry, enzymology. SUBSTANCE: invention relates to the use of derivatives of azo-bis-(1,2,6-oxadiazole) of the corresponding structural formula (I): 
where if m = 0 then n = x =0; y = 2-12 and z = 1; or n = x = 1 and z = 2; or n = x = z = 1 and y = 3; or n = y = 1, x = 0 and z = 2 or 3; or if m = 1 then n = x = 0, y = 3 and z = 1 as inhibitors of guanylate cyclase soluble form. The use of compounds of the general formula (I) where m = n = x = 0, y = 2-12 and z = 1 is preferable. The use of derivatives of azo-bis-(1,2,5-oxadiazole) of the general formula (I) where m = n = x = 0, y = 4 or 8 and z = 1 as inhibitor of basal activity and heme-independent stimulation of guanylate cyclase soluble form is preferable. The use of derivative of azo-bis-(1,2,5-oxadiazole) of the general formula (I) where m = n = x = 0, y = 8 and z = 1 as inhibitor of NO-dependent activation of guanylate cyclase soluble form is preferable. Proposed compounds show the more expressed inhibitory effect on basal activity and heme-independent stimulation of guanylate cyclase soluble form by effect of protoporphyrin-IX and Mn2+ ions and also on heme-dependent NO-mediated stimulation by effect of sodium nitroprusside exceeding analogous effects of the known structural analog diamide. Invention can be used for investigation of regulatory effects of nitrogen oxide and mechanism of guanylate cyclase soluble form effect. EFFECT: broadened assortment of specific regulators of activity of this enzyme. 4 cl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| INHIBITOR OF GUANYLATE CYCLASE SOLUBLE FORM | 2001 |
|
RU2196175C2 |
| INHIBITOR OF NO-DEPENDENT ACTIVATION OF GUANYLATE CYCLASE SOLUBLE FORM | 2001 |
|
RU2188865C1 |
| DONOR OF NITROGEN OXIDE AND ACTIVATOR OF GUANYLATE CYCLASE SOLUBLE FORM | 1997 |
|
RU2123046C1 |
| 1,2,5-OXADIAZOLO[3,4-D]PYRIDAZINE-5,6-DIOXIDE DERIVATIVES AS ACTIVATORS OF SOLUBLE FORM OF GUANYLATE-CYCLASE AND AGENTS ACTIVE IN TREATMENT OF CENTRAL NERVOUS SYSTEM, AND COMPOSITIONS BASED ON THESE COMPOUNDS | 1997 |
|
RU2165256C2 |
| SPECIFIC REGULATOR OF ACTIVITY OF NUCLEOTIDE-DEPENDENT ENZYMES | 1997 |
|
RU2130490C1 |
| ACTIVATOR OF GUANYLATE CYCLASE SOLUBLE FORM | 1997 |
|
RU2122582C1 |
| INHIBITOR OF NO-DEPENDENT ACTIVATION OF SOLUBLE FORM OF GUANYLATE CYCLASE | 2001 |
|
RU2189392C1 |
| DERIVATIVES OF 1,4,2,5-DIOXADIAZINE | 2001 |
|
RU2212409C1 |
| DONOR OF NITROGEN OXIDE AND ACTIVATOR OF SOLUBLE FORM OF GUANYLATE CYCLASE | 1998 |
|
RU2139932C1 |
| DONOR OF NITROGEN OXIDE ACTIVATING SOLUBLE FORM OF GUANYLATE CYCLASE, INHIBITING PLATELET AGGREGATION AND EXHIBITING SPASMOLYTIC AND VASODILATING EFFECT | 2001 |
|
RU2208438C1 |
