FIELD: antibiotics. SUBSTANCE: invention describes new derivatives of tetracycline of the general formula (I) 
where values R1,R2,R3,R4 are given in the p. 1 of the invention claim. Compounds are able for accumulation in osseous tissue and show inhibitory effect on resorption and promoting effect on the ossification. EFFECT: enhanced effectiveness of compounds. 8 cl, 3 dwg, 6 tbl
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