FIELD: virology, veterinary science. SUBSTANCE: invention relates to preparing serum for serodiagnosis of foot and mouth disease type A and serum is obtained from guinea pigs and rabbits. Preliminary animal-donors are infected with adapted virus, subjected their for hyperimmunization and an antigen-containing material from the strain N 1707 "Armenia- -98" and adjuvant as components of the preparation are administrated. Periodicity and amount of doses is determined as sufficient to form specific antibodies in animal-donors blood. Virus used for hyperimmunization is cultured in the suspension culture of cells VNK-21, obtained virus is purified, concentrated and inactivated. For hyperimmunization of animal-donors antigen (activity in RSK is 1:16, not less) is used. Saponin, its analogs or oily adjuvants are used as an adjuvant. In 10 days after hyperimmunization animal-donors are subjected for bleeding and blood serum is obtained. EFFECT: increased activity and specificity of the preparation. 2 cl, 2 dwg, 4 tbl, 2 ex
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