METHOD OF SEPARATION OF RAPAMYCIN FROM IMPURITIES Russian patent published in 2000 - IPC

Abstract RU 2152998 C2

FIELD: antibiotics. SUBSTANCE: invention relates to extraction of tricycle macrolide antibiotic rapamycin from the concentrated extract of fermentation broth and from mother liquor concentrate. Method is carried out for some stages in any order, for example, by extraction of concentrate with the base aqueous solution in the first water-nonmiscible solvent. Then concentrate solution is extracted with alkali aqueous solution in water-nonmiscible solvent and the solution-concentrate is treated with the second nonaromatic hydrocarbon solvent. EFFECT: enhanced effectiveness, accelerated method. 7 cl, 1 dwg, 9 ex

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RU 2 152 998 C2

Authors

Gletsos Konstantin

Dates

2000-07-20—Published

1994-10-28—Filed