FIELD: antibiotics. SUBSTANCE: invention relates to extraction of tricycle macrolide antibiotic rapamycin from the concentrated extract of fermentation broth and from mother liquor concentrate. Method is carried out for some stages in any order, for example, by extraction of concentrate with the base aqueous solution in the first water-nonmiscible solvent. Then concentrate solution is extracted with alkali aqueous solution in water-nonmiscible solvent and the solution-concentrate is treated with the second nonaromatic hydrocarbon solvent. EFFECT: enhanced effectiveness, accelerated method. 7 cl, 1 dwg, 9 ex
| Title |
Year |
Author |
Number |
| RAPAMYCIN DERIVATIVES, A PHARMACEUTICAL COMPOSITION AND A METHOD OF IMMUNODEPRESSION STIMULATING |
1993 |
- Venling Kao
- Magid A.Abou-Gkharbia
- Robert L.Vogel
|
RU2126409C1 |
| RAPAMYCIN ESTERS |
1996 |
|
RU2160739C2 |
| RAPAMYCIN HYDROXYESTERS, METHOD OF THEIR SYNTHESIS AND METHODS OF TREATMENT |
1995 |
- Dzheral'D Stenli Skotnitski
- Kristina Luiza Leon
- Gaj Alan Shizer
|
RU2134267C1 |
| SUBSTITUTED PYRIMIDINES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, OR N-OXIDES, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1992 |
- Dzhon Vatson Ehllingboj
- Madelen Nikajdo
- Zhak Framros Bazhli
|
RU2113437C1 |
| C-22 STABILIZED DERIVATIVES OF RAPAMYCIN, METHOD OF IMMUNO- -SUPPRESSION INDUCING, METHOD OF TREATMENT AND PROPHYLAXIS OF TRANSPLANT REJECTION OR HOMOLOGOUS DISEASE, METHOD OF TREATMENT OR PROPHYLAXIS OF HYPERPROLIFERATIVE VASCULAR DISORDER |
1994 |
|
RU2152946C1 |
| TRIS-CARBAMIC ACID ESTERS, METHOD OF CHOLESTEROL ABSORPTION DECREASE, PHARMACEUTICAL COMPOSITION FOR CHOLESTEROL ABSORPTION DECREASE |
1994 |
- Tomas Dzhozef Kommons
- Donal'D Piter Strajk
- Krista Mari Ljakler
|
RU2130928C1 |
| METHOD OF SYNTHESIS OF [2-((8,9)-DIOXO-2,6-DIAZOBI-CYCLO-[5,2,0]NON-1(7)-EN-2-YL)ETHYL]PHOSPHONIC ACID, METHOD OF SYNTHESIS OF N-[3-(TERTIARY BUTYLOXY- CARBONYLAMINO)PROPYL]-2-AMINOETHYLPHOSPHONIC ACID DI-C-C-ALKYL ESTER, COMPOUNDS |
1998 |
- Asselin Andre Al'Fred
- Kinni Uill'Jam Ehlvin
- Shmid Dzhin
|
RU2205834C2 |
| RAPAMYCIN PREPARATIONS FOR ORAL USING |
1998 |
|
RU2184541C2 |
| DERIVATIVES OF [([2- (AMINO -3,4-DIOXO -1-CYCLOBUTENE -1-YL)AMINO]ALKYL)] ACIDS |
1992 |
- Uil'Jam Alvin Kinni[Us]
- Dinna Kolett Garrison[Us]
|
RU2039035C1 |
| DERIVATIVES OF SUBSTITUTED BENZOYLBENZENE-, BIPHENYL OR 2-OXAZOLEALKANOIC ACID OR THEIR PHARMACOLOGICALLY ACCEPTABLE SALTS, AND A METHOD OF THEIR SYNTHESIS |
1992 |
- Amedeo Arturo Fejlli[Us]
- Ehntoni Frehnk Kreft Iii[Us]
- Dzhon Genri Musser[Us]
|
RU2037481C1 |
