FIELD: medicine, pharmacy. SUBSTANCE: pharmaceutical composition has effective amount of prednizolon and pharmaceutically acceptable accessory substances: glucose or sucrose, starch, stearic acid and/or its salt. Mass ratio of these accessory substances = 1:(1.12-1.77):(0.003-0.03), respectively. Mass ratio prednizolon : glucose or sucrose = 1:(6.8-72.0). Composition can be made as tablet. Method of preparing the composition involves mixing prednizolon with accessory components, mixture wetting, humid granulation, drying, dry granulation, granules powdering and their forming. Granules powdering is carried out with mixture of starch, stearic acid and/or its salt in the mass ratio of components of this mixture = 1:(0.01-0.09). Starch amount for powdering is 10.5-19.0% of its content in composition. Composition is stable for 2 years, not less. Its composition provides rapid release of prednizolon from medicinal form. Invention can be used for treatment of patients with rheumatism, rheumatic inflammatory diseases, Addison's disease, adrenal cortex insufficiency and others. EFFECT: improved properties and quality of composition, enhanced effectiveness of treatment. 4 cl, 1 dwg, 1 tbl, 5 ex
