FIELD: organic chemistry. SUBSTANCE: invention describes method of preparing of the novel compound 4,10-diacetoxy-2α- -benzoyloxy-5β,20-epoxy-1,7β-dihydroxy-9-oxo-tax-11-ene- -13α-yl-(2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropionate trihydrate. Method involves crystallization of 4,10-diacet--oxy-2α-benzoyloxy-5β,20-epoxy-1,7β-dihydroxy-9-oxo--tax-11-ene-13α-yl-(2R,3S)-3-benzoylamino-2-hydroxy-3- phenylpropionate in mixture of water and aliphatic alcohol containing 1-3 carbon atoms followed by drying the obtained product under decreased pressure and relative humidity above 20%. Invention describes also this new compound that shows anticancer and antileukemic properties. EFFECT: new compound indicated above, improved method of preparing, valuable antitumor properties. 5 cl, 2 ex
Title |
Year |
Author |
Number |
METHOD OF SYNTHESIS OF (2R,3S)-3-TERTIARY-BUTOXYCARBONYLAMINO- -2-HYDROXY-3-PHENYLPROPIONATE-4-ACETOXY-2α-BENZOYLOXY--5β,20- -EPOXY--1,7β,10β-TRIHYDROXY-9-OXO-TAX-11-ENE-13α-YL TRIHYDRATE |
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