4,10-DIACETOXY-2α-BENZOYLOXY-5β,20-EPOXY-1,7β-DIHYDROXY- 9-OXO-TAX-11-ENE-13α-YL-(2R,3S)-3-BENZOYLAMINO-2-HYDROXY-3-PHENYLPROPIONATE TRIHYDRATE AND METHOD OF ITS PREPARING Russian patent published in 2000 - IPC

Abstract RU 2154642 C2

FIELD: organic chemistry. SUBSTANCE: invention describes method of preparing of the novel compound 4,10-diacetoxy-2α- -benzoyloxy-5β,20-epoxy-1,7β-dihydroxy-9-oxo-tax-11-ene- -13α-yl-(2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropionate trihydrate. Method involves crystallization of 4,10-diacet--oxy-2α-benzoyloxy-5β,20-epoxy-1,7β-dihydroxy-9-oxo--tax-11-ene-13α-yl-(2R,3S)-3-benzoylamino-2-hydroxy-3- phenylpropionate in mixture of water and aliphatic alcohol containing 1-3 carbon atoms followed by drying the obtained product under decreased pressure and relative humidity above 20%. Invention describes also this new compound that shows anticancer and antileukemic properties. EFFECT: new compound indicated above, improved method of preparing, valuable antitumor properties. 5 cl, 2 ex

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RU 2 154 642 C2

Authors

Zhan-Rene Otelehn

Ehrik Did'E

Frank Levejlle

Izabel' Tajep'E

Dates

2000-08-20Published

1996-01-23Filed