CRYSTALLINE POLYMORPHOUS FORM OF (S,S,S)-(N-(1-[2-CARBOXY-3- -N-MESYLLYSYLAMINO)PROPYL]-1-CYCLOPENTYLCARBONYL)TYROSINE, METHODS OF ITS SYNTHESIS, INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHOD OF PATIENT TREATMENT Russian patent published in 1999 - IPC

Abstract RU 2131869 C1

FIELD: organic chemistry, amino acid derivatives. SUBSTANCE: invention relates to crystalline α-polymorphous form of a compound of the formula (I) exhibiting an infrared spectrum in mineral oil (nujol) and having absorption bands at v = 3407, 3386, 3223, 3153, 1699, 1652, 1626, 1594, 1516, 1457 (nujol), 1377 (nujol), 1344, 1334, 1317, 1267, 1241, 1228, 1210, 1164, 1151, 1137, 1118, 1109, 1093, 1074, 1045, 1019, 1003, 981, 965, 911, 897, 862, 818, 800, 778, 762, 721 and 655 cm^-1 and also to a method of its synthesis, intermediates compounds used for its synthesis, compositions containing on said and the use of α-polymorphous form, for example, the composition inhibiting angiotensin. EFFECT: improved method of synthesis, angiotensin-inhibiting activity. 43 cl, 17 dwg, 6 tbl, 13 ex

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RU 2 131 869 C1

Authors

Piter Dzhejms Dann

Majkl Lesli Kh'Juz

Dates

1999-06-20—Published

1994-11-09—Filed