CYCLOALKYLENE OR HETEROCYCLOALKYLENE DERIVATIVES, PHARMACEUTICAL COMPOSITION, AEROSOL DEVICE, AND MEDICAL TREATMENT METHOD Russian patent published in 2000 - IPC

FIELD: medicine. SUBSTANCE: described are new cycloalkylene or heterocycloalkylene of general formula I: R²-Y-R³ wherein R² and R³ are independently Z-X¹-X²-X³-X⁴-X⁵ in which Z is amino, guanidino or amidino; Y is cyclo ((C_3-14)) alkylene or heterocyclo ((C_6-8)) alkylene, saturated or unsaturated alkylene containing one or two nitrogen oxygen atoms as heteroatoms; X¹ is ((C_3-6)) alkylene, oxa((C_4-6))alkylene or -X⁶-X⁷-X⁸- in which X⁷ is phenylene, cyclo((C_3-6))alkylene or heterocyclo ((C_3-6))alkylene, saturated or unsaturated, containing one or two nitrogen atoms as heteroatom, and X⁶ and X⁸ are (C_n6) alkylene and heterocyclo ((C_n8))alkylene respectively, wherein sum of n6 and n8 is equal to 1,2,3 or 4 provided that when Z is amino, n6 is other than 0; X² and X⁴ are independently , wherein each R¹ is independently hydrogen, ((C_1-8))alkyl; X³ is ((C_1-8))alkylene, -X⁹-X¹⁰- or -X¹⁰-X⁹- wherein X⁹ is (C_n9) alkylene wherein n9 is 0,1 or 1, and X¹⁰ is cyclo ((C_3-8))alkylene or heterocyclo ((C_3-8))alkylene saturated or unsaturated, containing one or two nitrogen atoms as heteroatom provided that there are no covalent bonds between heteroatoms contained in X¹⁰ and heteroatoms contained either in X² or X⁴; and X⁵ is ()alkylene wherein n5 is 0,1 or 2 provided that R² and R³ are different, and pharmaceutically acceptable salts thereof. Also described are compositions based on compounds of formula I, aerosol device and medical treatment method. Said compositions, compounds and methods are effective for prevention and medical treatment of mastocyte-induced inflammatory disorders, associated with respiratory paths, such as asthma or allergic rhinitis and also other types of immunoinduced inflammatory diseases such as rhemotoidal arthritis, conjutivitis and inflammatory disease of alimentary canal, various dermatological states and also some visual diseases. Compounds include potent and selective inhibitors of protease and triptase of mastocyte. EFFECT: improved properties of the title compounds and pharmacological composition. 48 cl, 8 dwg, 6 ex