4-ARYLOXY- OR 4-ARYLTHIOPIPERIDINE DERIVATIVES, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION CONTAINING ON SAID AND METHOD OF ITS PREPARING Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to 4-aryloxy- or 4-arylthio- -piperidine derivatives of the formula (I) where R¹ and R² each means independently each of other mono- or di-substituted residues with A, OH, OA, phenylmethoxy, -O-(CH₂)_n-O-, NH₂, NHAc, NAAc, NHSO₂A, fluorine or chlorine atom, phenyl; X means O, S or SO₂; m = 1; n = 2; A is C_1-6-atoms; Ac is C_1-4-alkanoyl and also their physiologically acceptable salts that effect on CNS being damping effect preferably. EFFECT: improved method of synthesis and preparing, central effects. 11 cl, 1 tbl, 21 ex