ANTIMIGRAINE INDOLE DERIVATIVE SALTS Russian patent published in 2000 - IPC

Abstract RU 2159241 C2

FIELD: pharmaceutical chemistry. SUBSTANCE: invention provides novel crystalline alpha-polymorphous hydrobromide salt of 3-(N-methyl-2(R)pyrrolidinylmethyl)-5-(2-phenyl- sulfonylethyl)-1H-indole [formula I: (I)] , characterized by infra-red spectrum in Nujol with strong absorption bands at ν = 3371, 3293, 2713, 2524, 1419, 1343, 1307, 1264, 1151, 1086, 1020, 1008, 999, 922, 900, 805, 758, 740, 728, 689, 672, 652, 640, 598, 581, 573, 531, 498, 465, 457, 443, 428, 422, 414, and 399 cm^-1. Compounds exhibit activity suitable for treatment of migraine and other conditions. EFFECT: increased choice of therapeutic preparations. 13 cl, 3 dwg, 2 tbl, 6 ex

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RU 2 159 241 C2

Authors

Valeri Deniz Kharding

Ross Dzhejms Makrae

Ronal'D Dzhejms Ogilvi

Dates

2000-11-20—Published

1995-05-17—Filed