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2 162 601

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Application

99111046/14, 1999-05-26

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Start date

1999-05-26

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Actual filing date

1999-05-26

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Published

2001-01-27

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Inventor

Kozlov L.V.Skorokhodova T.G.Batalova T.N.Lakhtin V.M.Matveevskaja N.S.Guzova V.A.D'Jakov V.L.

(73)

Holder

Moskovskij Nauchno-Issledovatel'Skij Institut Ehpidemiologii I Mikrobiologii Im. G.N. Gabrichevskogo

METHOD OF ASSAY OF FUNCTIONAL ACTIVITY OF COMPONENT C4 OF HUMAN COMPLEMENT Russian patent published in 2001 - IPC

Abstract RU 2162601 C1

FIELD: medicinal immunology. SUBSTANCE: invention relates to methods of assay of functional activity of complement components in human sera in diagnosis of some diseases and in biological preparations. Method is based on capacity of cellular wall lipopolysaccharides of gram-negative bacteria to activate the classic complement way and capacity of activated component C4 to bind covalently with activating agent. Method involves sorption of cellular wall lipopolysaccharide of gram-negative bacteria into micropanel wells. Then C4 to be analyzed from solutions containing its is sorbed in the presence of guinea pig serum. Amount of covalently bound component C4 as a result of activation is determined by product of enzymatic reaction using antibodies to C4-fraction of immunoglobulins. Method ensures to assay functional activity of component C4 in human complemet system by immunoenzymatic method. EFFECT: improved method of assay, reliability and confidence of method. 3 ex

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RU 2 162 601 C1

Authors

Kozlov L.V.

Skorokhodova T.G.

Batalova T.N.

Lakhtin V.M.

Matveevskaja N.S.

Guzova V.A.

D'Jakov V.L.

Dates

2001-01-27—Published

1999-05-26—Filed

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