FIELD: synthesis of biologically-active compounds. SUBSTANCE: invention provides method for preparing intermediates in synthesis of steroids with progestogenic activity, in particular ketal of steroid derivative with general formula I:
(I), wherein R1 expresses methyl or ethyl, R2 hydroxyl, R3 hydrogen, methyl or cyanomethyl, or R2 and R3 form together oxygen bridge; and R4 expresses C2-C5-alkylene, consisting in that compound of the general formula II:
(II), in which all symbols are the same as in formula I, is treated in presence of one or two ortho- ethers having formula III:
(III) and IV:
(IV), in which all symbols are the same as in formula I, by alcohol of general formula HOR4OH, wherein R4 is indicated above. EFFECT: enabled preparation of products with minimum amounts of impurities. 6 cl, 7 ex
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