4-AMINO-1-PIPERIDYLBENZOYLGUANIDINES OR THEIR PHYSIOLOGICALLY ACCEPTABLE SALTS, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF ITS PREPARING Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to 4-amino- -1-piperidylbenzoylguanidines of the formula (I) where R¹, R² - H, A, CO-Ph, CO-Het or aminoprotective group, or R¹, R² in common mean C_4-5-alkylene being one CH₂-group can be substituted with -CO-, -NH-, -NA-group, or in common with nitrogen atom form dihydrobenzimidazole residue; R³, R⁴ - H, A, halogen atom, -XR⁵, CN, NO₂, CF₃, SO₂-NR⁵R⁶, SO₂R⁷; R⁵ - H, A, Ph; R⁶ - H, A; R⁷ - A; X is -O-, -N-R⁶; A is C_1-6-alkyl; halogen atom - fluorine, chlorine, bromine or iodine atom; Ph - possibly mono-, di- or trisubstituted A, OA, halogen-phenyl; Het - pyridyl or their physiologically acceptable salts that show good cardioprotective effect. EFFECT: improved methods of synthesis and preparing, valuable pharmacological property. 7 cl, 1 tbl, 1 dwg