DERIVATIVES OF CYCLOPEPTIDES AS ADHESION INHIBITORS Russian patent published in 2003 - IPC

FIELD: organic chemistry of peptides. SUBSTANCE: invention relates to a group of novel compounds of the general formula (I): where A means Gly; B means a residue of the formula (II): where m = 0 or 1; n = 2 or 3; each of R¹ and R² means independently H; R¹ and R² both in common mean also: or , where q = 1, 2 or 3; r = 0 or 1 or -CO-CH=CH-CO-; X means H, Cl or C₁-C₆-alkyl and in the case of the presence of residues of optically active amino acids and derivatives of amino acids the invention involves both D- and L-forms of amino acids and their salts also. Invention relates also to method of synthesis of compounds of the formula (1) and their salts, to pharmaceutical composition eliciting ability to inhibit integrin activity and comprising at least one compound of the formula (1) and/or one of its physiologically acceptable salts. EFFECT: valuable biological properties of compounds. 6 cl, 3 tbl, 8 ex