FIELD: medicine. SUBSTANCE: the method suggests to obtain a natural mixture of interdependent estrogens which is deficient in phenolic substances out of pregnant mares' urine. Urine or its concentrate is treated with a water-soluble foundation, put into contact with hydrophobized silica gel, then the gel is washed with a buffer solution and put into contact with eluting fluid to desorb the mixture of interdependent estrogens. EFFECT: higher efficiency. 6 cl, 1 tbl
