FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of urea of the general formula (I) 
where R1 means hydrogen atom or lower alkyl; R2 means hydrogen or halogen atom; R3 means hydrogen atom or lower alkoxy-group and to their physiologically compatible acid-additive salts. Invention describes also method of synthesis of compounds in two variants and medicinal agent. Derivatives of urea exhibit antagonistic properties with respect to neurokinin receptors and pattern of effect that is favorable for treatment of functional and inflammatory disorders of gastroenteric tract in higher mammals. EFFECT: improved methods of synthesis, valuable medicinal properties. 5 cl, 3 tbl
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Year |
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Number |
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