FIELD: medicine, pharmacy. SUBSTANCE: invention relates to a pharmaceutical composition containing c-kit-ligand and hemopoietic factor, method of enhancement of levels of stem cells in peripheral blood, antagonist of c-kit-ligand, antisense molecule of nucleic acid, method of enhancement of levels of stem cells in peripheral blood ex- vivo. Invention involves pharmaceutical composition based on c-kit-ligand that is a polypeptide encoded by nucleic acid SEQ ID NO:1 or natural hemopoietic variant of polypeptide and effective amount of hemopoietic factor, method of enhancement of levels of stem cells in peripheral blood using the indicated composition. Also, invention relates to antisense nucleic acids used as therapeutic agents and method of enhancement of levels of cells in peripheral blood ex-vivo including treatment of peripheral blood cells with indicated composition ex-vivo. EFFECT: development of novel hemopoietic agent. 14 cl, 35 dwg, 3 tbl, 3 ex
| Title |
Year |
Author |
Number |
| COMPOSITION AND METHOD FOR ELEVATING AMOUNT OF STEM CELLS AND/OR HEMOPOIETIC CELL-PRECURSORS IN CIRCULATION IN PERIPHERAL BLOOD OF MAMMALS |
2001 |
- Ferro Laura
- Porta Roberto
- Jakobelli Massimo
- Dzhanni Alessandro Massimo
- Stella Karmelo Karlo
|
RU2248216C2 |
| COMPOSITION FOR STIMULATION AND ENHANCEMENT OF PRODUCTION OF ANTIBODY THAT RECOGNIZE GANGLIOSIDE |
1994 |
- Filip O. Livingston
- Fridkhehl'M Khelling
|
RU2174013C2 |
| METHOD OF CULTIVATION, FIBROBLASTS, METHOD OF CELL SEPARATION |
1991 |
- Stefan G. Ehmerson
- Majkl F. Klarke
- Bernard O. Pehlsson
- Richard M. Shvartts
|
RU2164240C2 |
| PHARMACEUTICAL COMPOSITION USED FOR STEM CELLS MOBILISATION |
2004 |
- Dzhanni Alessandro Massimo
- Karlo-Stella Karmelo
- Kolotta Franchesko
|
RU2351357C2 |
| METHODS FOR ACTIVATION OF CELLS-PRECURSORS/STEM CELLS |
2002 |
- Bridzher Gari Dzh.
- Ehbrams Majkl Dzh.
- Khenson Dzheffri V.
- Makfarlehnd Ronal'D Trevor
- Kalandra Gari B.
- Dejl Devid S.
- Broksmejer Khel Eh.
|
RU2309741C2 |
| POLYPEPTIDE-LIGAND FLT3 (VARIANTS), POLYNUCLEOTIDE (VARIANTS), EXPRESSING VECTOR (VARIANTS), STRAIN OF CELL CHO (VARIANTS), METHOD FOR PRODUCING POLYPEPTIDE-LIGAND FLT3 (VARIANTS), PHARMACEUTICAL COMPOSITION (VARIANTS) |
1994 |
- Lajmehn Stjuart D.
- Bekmann M. Patritsija
|
RU2220979C2 |
| HEMOPOIETIC PROTEIN (VARIANTS), DNA SEQUENCE, METHOD FOR PREPARING HEMOPOIETIC PROTEIN, METHOD FOR SELECTIVE EXPANSION OF HEMOPOIETIC CELLS, METHOD FOR PRODUCING DENDRITIC CELLS, METHOD FOR STIMULATING FOR PRODUCING HEMOPOIETIC CELLS IN PATIENT, PHARMACEUTICAL COMPOSITION, METHOD FOR TREATMENT |
1997 |
- Mak Verter Charl'Z A.
- Feng Jikving
- Mak Kern Dzhon P.
- Sammers Nina L.
- Stehjten Nikolas R.
- Striter Filip R.
- Minnerli Dzhon K.
- Minster Nehnsi I.
- Vul'F S'Juzn L.
|
RU2245887C2 |
| COMPOSITIONS AND METHODS OF IMMUNOTHERAPY |
2014 |
- Brentdzhens Rener Dzh.
- Dzhekson Kholli Dzh.
|
RU2680010C2 |
| METHOD FOR STABLE CELL TRANSDUCTION BY VIRAL VECTORS |
2001 |
- Jumo Loran
- Khan Vej
- Lu Ksiaobin
- Slepushkin Vladimir
- Lesher Mishell'
- Dehvis Brajan
- Chang Jung-Nien
- Dropulik Boro
|
RU2280074C2 |
| REPROGRAMMING HUMAN ENDOTHELIUM IN HEMATOPOIETIC PRECURSORS OF MULTIPLE LINES OF DIFFERENTIATION USING CERTAIN FACTORS |
2014 |
- Sandler Vladislav M.
- Rafii Shakhin
|
RU2691062C2 |
