FIELD: biotechnology, genetic and protein engineering. SUBSTANCE: invention relates to the constructed recombinant plasmid DNA p7SHSHis for production of dimeric single-stranded antibodies of tick-borne encephalitis virus of molecular mass 2.5 Md. The strain of bacterium E. coli B-774 is transformed with recombinant plasmid p7SHSHis. Firstly obtained plasmid DNA and the bacterial strain-producer provide expression of dimeric form of single-stranded antibodies of tick-borne encephalitis virus retaining the conformation of variable domain of the parent monoclone antibodies. EFFECT: plasmid and strain-producer indicated above, valuable biological properties. 2 cl, 7 dwg
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Year |
Author |
Number |
| RECOMBINANT PLASMID DNA PTLS CONTAINING GENE OF SINGLE-STRANDED ANTIBODY AGAINST TICK-BORNE ENCEPHALITIS VIRUS AND STRAIN OF BACTERIUM ESCHERICHIA COLI AS PRODUCER OF SINGLE-STRANDED ANTIBODIES AGAINST TICK-BORNE ENCEPHALITIS VIRUS |
1998 |
- Nikolenko G.N.
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- Deev S.M.
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2008 |
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1997 |
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2018 |
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| RECOMBINANT PLASMID DNA PC-NS3 PROVIDING INTEGRATION OF COMPLEX OF GENES C, PRM, E, NS1, NS 2A, NS 2B, NS3 OF TICK-BORNE ENCEPHALITIS VIRUS IN GENOME OF BOVINE VACCINE VIRUS AND RECOMBINANT STRAIN OF BOVINE VACCINE VIRUS EXPRESSING COMPLEX OF GENES C, PRM, E, NS1, NS 2A, NS2B, NS3 OF TICK-BORNE ENCEPHALITIS VIRUS IN IMMUNIZED ORGANISM CELLS |
1995 |
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1995 |
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- Il'Ichev A.A.
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RU2112039C1 |
| RECOMBINANT PLASMID DNA PUHBC ENCODING GENE OF HEPATITIS VIRUS B CORE ANTIGEN PROTEIN AND ENSURING TO EXHIBIT FOREIGN EPITOPES ON THE CORE SURFACE |
1995 |
- Karpenko L.I.
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- Il'Ichev A.A.
|
RU2121504C1 |
| METHOD OF IMMUNIZATION AGAINST INFECTION CAUSED BY TICK-BORNE ENCEPHALITIS VIRUS |
1997 |
- Goncharova E.P.
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| RECOMBINANT FRAGMID DNA pHEN-TAB CONTAINING HUMAN SINGLE-STRAND ANTIBODY GENE, CAPABLE OF BINDING OF HUMAN TUMOR NECROSIS FACTOR ALPHA; RECOMBINANT Escherichia coli BACTERIA STRAIN AS PRODUCER OF HUMAN SINGLE-STRAND ANTIBODY AGAINST HUMAN TUMOR NECROSIS FACTOR ALPHA; RECOMBINANT SOLUBLE HUMAN SINGLE-STRAND ANTIBODY AGAINST HUMAN TUMOR NECROSIS FACTOR ALPHA |
2005 |
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|
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1998 |
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- Razumov I.A.
- Kazachinskaja E.I.
- Kachko A.V.
- Ivanova A.V.
- Mishin V.P.
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