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2 190 017

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Application

2000116814/13, 2000-06-26

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Start date

2000-06-26

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Actual filing date

2000-06-26

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Published

2002-09-27

(72)

Inventor

Nikolenko G.N.Tikunova N.V.Protopova E.V.Loktev V.B.Karpenko L.I.Konovalova S.N.Il'Ichev A.A.

(73)

Holder

Gosudarstvennyj Nauchnyj Tsentr Virusologii I Biotekhnologii

RECOMBINANT PLASMID DNA P7SHSHIS FOR PRODUCTION OF DIMERIC SINGLE-STRANDED ANTIBODY AGAINST TICK-BORNE ENCEPHALITIS VIRUS AND STRAIN OF ESCHERICHIA COLI AS PRODUCER OF DIMERIC FORM OF SINGLE-STRANDED ANTIBODY AGAINST TICK-BORNE ENCEPHALITIS VIRUS Russian patent published in 2002 - IPC

Abstract RU 2190017 C2

FIELD: biotechnology, genetic and protein engineering. SUBSTANCE: invention relates to the constructed recombinant plasmid DNA p7SHSHis for production of dimeric single-stranded antibodies of tick-borne encephalitis virus of molecular mass 2.5 Md. The strain of bacterium E. coli B-774 is transformed with recombinant plasmid p7SHSHis. Firstly obtained plasmid DNA and the bacterial strain-producer provide expression of dimeric form of single-stranded antibodies of tick-borne encephalitis virus retaining the conformation of variable domain of the parent monoclone antibodies. EFFECT: plasmid and strain-producer indicated above, valuable biological properties. 2 cl, 7 dwg

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RU 2 190 017 C2

Authors

Nikolenko G.N.

Tikunova N.V.

Protopova E.V.

Loktev V.B.

Karpenko L.I.

Konovalova S.N.

Il'Ichev A.A.

Dates

2002-09-27—Published

2000-06-26—Filed