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(51)

IPC

(21) (22)

Application

95114192/13, 1995-08-08

(22)

Actual filing date

1995-08-08

(45)

Published

1998-11-10

(72)

Inventor

Karpenko L.I.Chikaev N.A.Il'Ichev A.A.

(73)

Holder

Gosudarstvennyj Nauchnyj Tsentr Virusologii I Biotekhnologii

RECOMBINANT PLASMID DNA PUHBC ENCODING GENE OF HEPATITIS VIRUS B CORE ANTIGEN PROTEIN AND ENSURING TO EXHIBIT FOREIGN EPITOPES ON THE CORE SURFACE Russian patent published in 1998 - IPC

Abstract RU 2121504 C1

FIELD: molecular biology, genetic engineering. SUBSTANCE: invention relates to recombinant plasmid DNA pUHBc that encodes hepatitis B core antigen protein. Its molecular mass is 2.36 MDa and size is 3576 base pairs. Recombinant plasmid DNA has plasmid vector pUC 19, promoter Plac, unique restriction sites for Nde (183), Nar I (236), Afl III (806), Cfr 10 I (1779). Ssp I (2501), Bam HI-fragment containing hepatitis B virus C-gene, genetic markers and gene of resistance to ampicillin. Invention ensures to exhibit foreign epitopes located on capsid HBc Ag surface and can be used as a basis for new structures making. EFFECT: plasmid DNA indicated above. 5 dwg, 4 ex

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RU 2 121 504 C1

Authors

Karpenko L.I.

Chikaev N.A.

Il'Ichev A.A.

Dates

1998-11-10—Published

1995-08-08—Filed

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