FIELD: molecular biology methods. SUBSTANCE: method is, in particular, applicable for analyzing medical samples and envisages: providing a solid support system with, attached to it, single-chain oligonucleotide complementary to specific sequence on target nucleic acid, which is longer than mentioned oligonucleotide; adding source of single-chain target nucleic acid to solid support system; hybridization of target nucleic acid with oligonucleotide; and performing manipulation on hybridized target nucleic acid. Manipulation can, for instance, be copying and amplification of target nucleic acid sequence. In a preferable realization mode, one provides support in a flow vessel, which facilitates washing of support to remove impurities and remain "pure" target nucleic acid sample fit for manipulation. Advantageously, support has siloxanes matrix, to which oligonucleotide is more reliably bound. EFFECT: facilitated manipulations with nucleic acid sequence for medical purposes. 47 cl, 11 dwg, 3 ex
