FIELD: organic chemistry, medicine, virology, pharmacy. SUBSTANCE: anti-HIV- composition comprises 2-carbamoylhydroxymethyl-5-(3,5-dichlorophenylthio)-4-isopropyl-1-(pyridine- 4-yl)-methyl-1H-imidazole or its pharmaceutically acceptable salt and distinct from its one or some compounds showing an anti-HIV-activity taken in synergetically effective amount. Preparations AZT, ddI, ddC, 3TC, saquinavir and/or foscarnet are used as compounds showing an anti-HIV-activity. A novel combination eliciting synergetic effect provides decrease of adverse effects, for example, toxicity. It inhibits also the development of viral drug resistance effectively that provides the efficient and effective treatment of patients with AIDS. EFFECT: enhanced effectiveness of composition and treatment. 6 cl, 4 dwg, 18 tbl
| Title |
Year |
Author |
Number |
| METHODS AND COMPOSITIONS FOR TREATING HIV INFECTION |
2005 |
- Lin Pin-Fang
- Novitska-Senz Beata
- Jamanaka Gregori
|
RU2367439C2 |
| BENZOXAZINONES AND PHARMACEUTICAL COMPOSITION COMPRISING THEREOF FOR INHIBITION OF ACTIVITY OF HIV REVERSE TRANSCRIPTASE, TREATMENT AND PROPHYLAXIS OF AIDS AND ARS, METHOD OF INHIBITION OF ACTIVITY OF HIV REVERSE TRANSCRIPTASE, METHOD OF PROPHYLAXIS OF HIV INFECTION, TREATMENT OF HIV AND ARS, COMBINATIONS, METHOD OF SYNTHESIS OF (-)-6-CHLORO- -4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4- -DIHYDRO-2H-3,1-BENZOXAZINE-2-ONE |
1993 |
- Jang Stiven D.
- Britcher Sjuzn F.
- Pejn Linda S.
- Tran Likkhan O.
- Lamma Vill'Jam K. Ml.
|
RU2186775C2 |
| PHARMACEUTICAL AGENT FOR TREATMENT OF HIV-INFECTION, COMPOSITION CONTAINING THEREOF AND METHODS FOR ITS USING |
2002 |
- Chzhou Gehn'Fa
- Tjan' Vanni
|
RU2290197C2 |
| ANTIVIRAL COMPOSITION CONTAINING NUCLEOSIDE ANALOG, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT |
1992 |
- Dzhanet Mehri Kameron
- Nikolas Kammak
|
RU2139059C1 |
| INHIBITORS OF HIV-PROTEASE |
1994 |
- Dzhoel R.Khaff
- Dzhozef P.Vakka
- Brjus D.Dorsi
|
RU2137768C1 |
| TREATMENT OF HIV INFECTION AT MEDICINAL RESISTANCE |
2000 |
- Khostetler Karl I.
- Mellors Dzhon U.
|
RU2265439C2 |
| HIV-INHIBITING 2-(4-CYANOPHENYLAMINO)-PYRIMIDINE-OXIDE DERIVATIVES |
2006 |
- De Kok Kherman Augustinus
- Vigerink Pit Tom Bert Pol'
|
RU2398768C2 |
| BENZOTHIOPHEMECARBOXAMIDE DERIVATIVES, ANTAGONISTS OF PROSTAGLANDIN D CONTAINING THEREOF, PHARMACEUTICAL COMPOSITION AND DRUG |
1997 |
- Khonma Tsunetoshi
- Khiramatsu Joshikharu
- Arimura Akinori
|
RU2161617C1 |
| PHARMACEUTICAL COMPOSITION COMPRISING EFFECTIVE AMOUNT OF β-2',3'-DIDEHYDRO-2',3'-DIDEOXY-5-FLUOROCYTIDINE AND METHOD FOR TREATMENT OR PROPHYLAXIS IF HIV-INFECTION IN HUMANS |
2000 |
- Shinazi Rehjmond F.
- Khammond Dzhennifer
- Mellors Dzhon V.
- Liotta Dennis K.
|
RU2254133C2 |
| COMBINATION OF HIV-PROTEASE INHIBITOR WITH OTHER ANTIVIRAL COMPOUNDS, PHARMACEUTICAL COMPOSITION BASED ON SAID AND METHOD OF PHARMACEUTICAL COMPOSITION PREPARING |
1994 |
- Dzhozef P.Vakka
- Dzhejms P.Gar
- Brjus D.Dorsi
- M.Katarin Khollouehj
- Rehndall V.Khangejt
|
RU2139052C1 |
