ASSOCIATED VACCINE FOR PROPHYLAXIS OF ANTHRAX AND NECROBACTERIOSIS IN ANIMALS Russian patent published in 2002 - IPC

FIELD: veterinary science, biotechnology. SUBSTANCE: vaccine contains aluminium hydroxide-adsorbed formalin-inactivated leucocidine- exotoxin, suspension of alive spores of anthracic vaccine strain 55-VNIIVV&M at initial concentration being (5-5,5)•10⁹ spores/cm³ in physiological solution, 1 M-sodium metabisulfite solution and an oily adjuvant. Vaccine components are in a balanced ratio. Leucocidine-exotoxin is a highly purified protein at 18-20 kDa molecular weight. It is obtained out of production strain Fusobacterium necrophorum "0-1" VIEV. Associated vaccine is once injected for cattle, sheep, goats, pigs and Siberian stags intracutaneously with the help of a needle-free injector at 0.2-0.4 cm³ volume. Associated vaccine against anthrax and necrobacteriosis is a highly efficient preparation to protect animals against these diseases, according to its immunogenicity it surpasses monovaccines that it contains. EFFECT: higher efficiency of prophylaxis. 2 ex