DERIVATIVES OF PYRROLE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF TREATMENT Russian patent published in 2003 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention describes novel derivatives of pyrrole of the formula (I-1) or (I-3) or its pharmacologically acceptable salt, ester or amide derivative where R¹, R² are given in the invention claim; R³ means quinuclidine-2-ene-3-yl group, 8-methyl-8-azabicyclo[3.2.1]oct-2-ene-3-yl group, 8-azabicyclo[3.2.1] oct-2-ene-3-yl group or group of the formula (II) where m = 0 or 1; n = 1 or 2; R⁵, R⁷, R⁶, R⁸, R⁹, D, E, R¹⁰, R¹¹, R¹² are describes in the invention claim. New compounds show inhibitory activity against induction of biosynthesis of inflammatory cytokines. Also, invention describes pharmaceutical compositions and method of treatment or prophylaxis of sicknesses. EFFECT: improved method of treatment, valuable medicinal properties of compounds. 31 cl, 3 tbl