FIELD: medicine, pharmacy. SUBSTANCE: invention relates to pharmaceutical composition made as granule that comprises antifungal compound itraconazole or superconazole. Granules comprise inert core of size from 50 to 600 mcm and coating layer. Coating involves a single layer prepared by spraying on indicated inert core of solution involving itraconazole or superconazole, hydrophilic polymer and nonionic surface-active substance. Coating layer is applied at the constant rate for all process. Indicated coating layer is subjected for a single drying stage at 45 C being application of coating layer and its drying are carried out into the same apparatus that provides the improvement of chemical and physical integrity of granules. Pharmaceutical composition provides the improved solubility of indicated antifungal compounds and their enhanced bioavailability. EFFECT: improved preparing method, reduced price and time of process. 7 cl, 1 ex
