DERIVATIVES OF HYDROXYIMINOALKANOIC ACID, PHARMACEUTICAL COMPOSITION AND AGENT FOR REGULATION OF RETINOID RECEPTORS Russian patent published in 2003 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel derivatives of hydroxyiminoalkanoic acid of the formula (I) wherein R¹ represents oxazolyl optionally substituted with 1-2 substituents taken among lower alkyl, phenyl, thienyl, furyl; thiazolyl optionally substituted with 1-2 substituents taken among lower alkyl, phenyl; unsubstituted quinolinyl and so on; X represents a linkage or group NR⁶ wherein R⁶ represents hydrogen atom or C_1-4-alkyl; n is a whole number from 1 to 3; Y represents oxygen atom or group NR⁷ wherein R⁷ represents hydrogen atom; ring A represents benzene ring optionally substituted with one or two C_1-4-alkoxy-group; p is a whole number from 1 to 3; R² represents phenyl optionally substituted with lower alkyl, halogen atom and so on; unsubstituted furyl; unsubstituted pyridyl; pyridinyl-1-oxide; q is a whole number from 0 to 6; m represents 0 or 1; R³ represents hydroxy-group, lower alkoxy-group or -NR⁹R¹⁰ wherein R⁹ and R¹⁰ represent similar or different groups taken among hydrogen atom, lower alkyl and lower alkylsulfonyl; R⁴ and R⁵ represent similar or different groups taken among hydrogen atom or lower alkyl; or their salt. Invention relates also to pharmaceutical composition eliciting hypoglycemic and hypolipidemic effects containing compound of the formula (I) and pharmacologically acceptable carrier and to agent used for regulation of retinoid receptors containing compound of the formula (I). Invention provides preparing novel derivatives of hydroxyiminoalkanoic acid showing hypoglycemic and hypolipidemic effects. EFFECT: valuable medicinal and pharmacological properties of compounds. 21 cl, 2 dwg