FIELD: genetic engineering, medicine. SUBSTANCE: invention relates to the prepared receptor body that is able to bind specifically ligand TIE-2 that comprises extracellular moiety of receptor TIE-2 fused with constant region of human immunoglobulin. Invention proposed plasmid vTIE-2/receptor body containing nucleic acid for expression of receptor body. Pharmaceutical composition contains effective amount of receptor body TIE-2 that is used in method for prevention or attenuation of neovascularization in mammals. Invention provides carrying out diagnosis and treatment of disease concerning endothelial cells comprising receptors TIE-2. Invention provides the development of diagnostic systems for identification of agonist or antagonists of receptor TIE-2. Invention relates specifically to genes encoding tyrosine kinase receptors and can be used for diagnosis. EFFECT: valuable properties of receptor body. 6 cl, 12 dwg, 12 ex
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Year |
Author |
Number |
| NUCLEIC ACID MOLECULE ENCODING LIGAND TIE-2, LIGAND TIE-2 AND METHOD FOR ITS PREPARING, VECTOR, STRAIN OF CELLS COS, ANTIBODY, CONJUGATE OF LIGAND TIE-2, LIGAND BODY, PHARMACEUTICAL COMPOSITION, METHOD FOR PROPHYLAXIS OR ATTENUATION OF NEOVASCULARIZATION AND METHOD FOR IDENTIFICATION OF TIE-2 RECEPTOR ANTAGONIST |
1995 |
- Dehvis Sehmjuehl'
- Bruno Dzhoan
- Goldfarb Mitchell
- Oldrich Tomas Kh.
- Mehjsonp'Er Piter S.
- Radzievski Cheslav
- Dzhons Pamela F.
- Jankopulos Dzhordzh D.
|
RU2233330C2 |
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1997 |
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|
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1995 |
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|
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1997 |
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2000 |
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