FIELD: genetic engineering, molecular biology, biochemistry, medicine, pharmacy.
SUBSTANCE: invention relates to genes encoding tyrosine kinases and can be used for diagnosis. Human ligand TIE-2 represents TIE-2 receptor antagonist. Ligand TIE-2 is prepared using vector pBluescript KS that comprises nucleic acid encoding ligand TIE-2. Conjugate is prepared by coupling ligand TIE-2 with cytotoxic agent. Ligand body represents ligand TIE-2 fused with immunoglobulin contact site. Pharmaceutical composition contains effective amount of ligand TIE-2 or ligand body and it is used in method for prophylaxis or attenuation of neovascularization. Invention provides diagnosis and treatment of diseases associated with endothelial cells comprising TIE-2 receptors. Invention provides the development of diagnostic systems for identification of TIE-2 receptor antagonist.
EFFECT: improved prophylaxis and treatment method, valuable medicinal properties of ligand.
16 cl, 14 dwg, 12 ex
| Title |
Year |
Author |
Number |
| ISOLATED NUCLEIC ACID MOLECULE ENCODING LIGAND TIE-2, LIGAND TIE-2 AND METHOD FOR PREPARING, PLASMID (VARIANTS), ANTIBODY, CONJUGATE, LIGAND BODY, PHARMACEUTICAL COMPOSITION, METHOD FOR STIMULATING NEO-VASCULARIZATION, METHOD FOR CELL MAINTENANCE, METHOD FOR IDENTIFYING TIE-2 RECEPTOR ANTAGONIST |
1995 |
- Dehvis Sehmjuehl'
- Bruno Dzhoan
- Goldfarb Mitchell
- Oldrich Tomas Kh.
- Mehjsonp'Er Piter S.
- Radzievski Cheslav
- Dzhons Pamela F.
- Jankopulos Dzhordzh D.
|
RU2232812C2 |
| RECEPTOR BODY SPECIFICALLY BINDING LIGAND TIE-2, ISOLATED NUCLEIC ACID MOLECULE, PLASMID, PHARMACEUTICAL COMPOSITION AND METHOD FOR PREVENTION OR ATTENUATION OF NEOVASCULARIZATION IN MAMMALS |
1995 |
- Dehvis Sehmjuehl'
- Bruno Dzhoan
- Goldfarb Mitchell
- Oldrich Tomas Kh.
- Mehjsonp'Er Piter S.
- Radzievski Cheslav
- Dzhons Pamela F.
- Jankopulos Dzhordzh D.
|
RU2216593C2 |
| ISOLATED NUCLEIC ACID MOLECULE ENCODING CHIMERIC TIE-2-LIGAND (VARIANTS), CHIMERIC OR MODIFIED TIE-2-LIGAND AND METHOD FOR ITS PREPARING, VECTOR, METHOD FOR PREPARING SYSTEM VECTOR-HOST, CONJUGATE, PHARMACEUTICAL COMPOSITION |
1997 |
- Dehvis Sehmjuel'
- Jankopoulos Dzhordzh D.
|
RU2233880C2 |
| ISOLATED TIE-LIGAND-4 AND ITS ISOLATED FIBRINOGEN-LIKE DOMAIN; ISOLATED NUCLEIC ACID MOLECULE ENCODING INDICATED LIGAND; VECTOR COMPRISING INDICATED NUCLEIC ACID; METHOD FOR PREPARING HOST-CELL TRANSFORMED WITH INDICATED VECTOR; METHOD FOR PREPARING TIE-LIGAND-4; CONJUGATE COMPRISING INDICATED LIGAND; LIGAND-BODY COMPRISING INDICATED FIBRINOGEN-LIKE DOMAIN |
1997 |
- Valenzuela Dehvid M.
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- Jankopoulos Dzhordzh D.
|
RU2242514C2 |
| RECEPTORS-MEDIATED DELIVERY OF GENES BY USING VECTORS BASED UPON BACTERIOPHAGES |
1998 |
- Larokka Dehvid
- Behjrd Ehndrju
- Dzhonson Uehndi
|
RU2209088C2 |
| NEW CYTOKINE ZALPHA 11-LIGAND |
2000 |
- Novak Dzhulija Eh.
- Presnell Skott R.
- Spreker Sindi A.
- Foster Donald K.
- Kholli Richard D.
- Gross Dzhejn A.
- Dzhonston Dzhehnet V.
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RU2258710C2 |
| METHOD FOR DETECTING LEPTIN RECEPTOR LIGANDS |
2003 |
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RU2373534C2 |
| METHOD FOR IDENTIFICATION OF BACTERIOPHAGE, METHOD FOR ISOLATION OF MAMMAL CELLS, METHOD FOR SELECTION OF BACTERIOPHAGE (VARIANTS), METHOD FOR IDENTIFICATION OF BACTERIOPHAGE SUBGROUP AND INTERNALIZING LIGAND (VARIANTS) |
1998 |
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RU2234530C2 |
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2003 |
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RU2325400C2 |
| POLYPEPTIDE-LIGAND FLT3 (VARIANTS), POLYNUCLEOTIDE (VARIANTS), EXPRESSING VECTOR (VARIANTS), STRAIN OF CELL CHO (VARIANTS), METHOD FOR PRODUCING POLYPEPTIDE-LIGAND FLT3 (VARIANTS), PHARMACEUTICAL COMPOSITION (VARIANTS) |
1994 |
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RU2220979C2 |
