FIELD: biotechnology, genetic engineering.
SUBSTANCE: invention can be used for preparing Tie-2 ligand. TIE-2 ligand is prepared by culturing cells transformed with vector comprising nucleotide sequence encoding TIE-2 ligand. TIE-2 ligand or ligand body comprising immunoglobulin region additionally is used as component of pharmaceutical composition for stimulation of neo-vascularization in mammal and for maintenance cell expressing TIE-2 receptor also. Antibody binding specifically with TIE-2 ligand is prepared by immunization of animal with TIE-2 ligand. Invention provides the development of agents used for diagnosis and treatment of diseases associated with endothelial cells.
EFFECT: improved stimulating method, valuable biological and medicinal properties of ligand.
19 cl, 17 dwg, 12 ex
| Title |
Year |
Author |
Number |
| NUCLEIC ACID MOLECULE ENCODING LIGAND TIE-2, LIGAND TIE-2 AND METHOD FOR ITS PREPARING, VECTOR, STRAIN OF CELLS COS, ANTIBODY, CONJUGATE OF LIGAND TIE-2, LIGAND BODY, PHARMACEUTICAL COMPOSITION, METHOD FOR PROPHYLAXIS OR ATTENUATION OF NEOVASCULARIZATION AND METHOD FOR IDENTIFICATION OF TIE-2 RECEPTOR ANTAGONIST |
1995 |
- Dehvis Sehmjuehl'
- Bruno Dzhoan
- Goldfarb Mitchell
- Oldrich Tomas Kh.
- Mehjsonp'Er Piter S.
- Radzievski Cheslav
- Dzhons Pamela F.
- Jankopulos Dzhordzh D.
|
RU2233330C2 |
| RECEPTOR BODY SPECIFICALLY BINDING LIGAND TIE-2, ISOLATED NUCLEIC ACID MOLECULE, PLASMID, PHARMACEUTICAL COMPOSITION AND METHOD FOR PREVENTION OR ATTENUATION OF NEOVASCULARIZATION IN MAMMALS |
1995 |
- Dehvis Sehmjuehl'
- Bruno Dzhoan
- Goldfarb Mitchell
- Oldrich Tomas Kh.
- Mehjsonp'Er Piter S.
- Radzievski Cheslav
- Dzhons Pamela F.
- Jankopulos Dzhordzh D.
|
RU2216593C2 |
| ISOLATED NUCLEIC ACID MOLECULE ENCODING CHIMERIC TIE-2-LIGAND (VARIANTS), CHIMERIC OR MODIFIED TIE-2-LIGAND AND METHOD FOR ITS PREPARING, VECTOR, METHOD FOR PREPARING SYSTEM VECTOR-HOST, CONJUGATE, PHARMACEUTICAL COMPOSITION |
1997 |
- Dehvis Sehmjuel'
- Jankopoulos Dzhordzh D.
|
RU2233880C2 |
| ISOLATED TIE-LIGAND-4 AND ITS ISOLATED FIBRINOGEN-LIKE DOMAIN; ISOLATED NUCLEIC ACID MOLECULE ENCODING INDICATED LIGAND; VECTOR COMPRISING INDICATED NUCLEIC ACID; METHOD FOR PREPARING HOST-CELL TRANSFORMED WITH INDICATED VECTOR; METHOD FOR PREPARING TIE-LIGAND-4; CONJUGATE COMPRISING INDICATED LIGAND; LIGAND-BODY COMPRISING INDICATED FIBRINOGEN-LIKE DOMAIN |
1997 |
- Valenzuela Dehvid M.
- Dzhounz Pamela F.
- Jankopoulos Dzhordzh D.
|
RU2242514C2 |
| RECEPTORS-MEDIATED DELIVERY OF GENES BY USING VECTORS BASED UPON BACTERIOPHAGES |
1998 |
- Larokka Dehvid
- Behjrd Ehndrju
- Dzhonson Uehndi
|
RU2209088C2 |
| METHOD FOR IDENTIFICATION OF BACTERIOPHAGE, METHOD FOR ISOLATION OF MAMMAL CELLS, METHOD FOR SELECTION OF BACTERIOPHAGE (VARIANTS), METHOD FOR IDENTIFICATION OF BACTERIOPHAGE SUBGROUP AND INTERNALIZING LIGAND (VARIANTS) |
1998 |
|
RU2234530C2 |
| GENETICALLY MODIFIED CELLS AND THEIR APPLICATION FOR PROPHYLAXIS OR TREATMENT OF SICKNESSES |
1998 |
- Khafemann Klaus
- Mjuller Rol'F
- Sedlachek Khans-Kharal'D
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RU2205029C2 |
| NEW CYTOKINE ZALPHA 11-LIGAND |
2000 |
- Novak Dzhulija Eh.
- Presnell Skott R.
- Spreker Sindi A.
- Foster Donald K.
- Kholli Richard D.
- Gross Dzhejn A.
- Dzhonston Dzhehnet V.
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- Dillon Stejsi R.
- Khehmmond Andzhela K.
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RU2258710C2 |
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2007 |
- Grinberg, Asja
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- Kumar, Ravindra
- Pirsall, Robert, Skott
- Sikhra, Dzhasbir
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RU2559532C2 |
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2003 |
- Jokkers Ral'F
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