METHOD FOR PREPARING QUINOLINE CARBALDEHYDE Russian patent published in 2003 - IPC

Abstract RU 2217423 C2

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to method for preparing 2-cyclopropyl-4-(4-fluorophenyl)-quinoline-3-carbaldehyde of the formula (I) that involves oxidation of 2-cyclopropyl-4-(4-fluorophenyl)-3-hydroxymethylquinoline with hypohalogenic acid salt in the presence of quaternary ammonium salt. 2-Cyclopropyl-4-(4-fluorophenyl)- quinoline-3-carbaldehyde can be used as an intermediate compound in synthesis of inhibitor of HNG-CoA- reductase using as medicinal agent for reduction of cholesterol level. Invention provides the development of simple and industrially favorable method for preparing 2-cyclopropyl-4-(4-fluorophenyl)-quinoline-3- carbaldehyde with high yield. EFFECT: improved preparing method. 2 cl, 2 ex

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RU 2 217 423 C2

Authors

Matsumoto Khiroo

Simisu Takanori

Takada Jasutaka

Dates

2003-11-27Published

1999-11-29Filed