FIELD: organic chemistry, chemical technology.
SUBSTANCE: invention relates to a method for preparing 3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]prop-2-ene nitrile. Method involves interaction of 2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-carbaldehyde with acetonitrile in the presence of a base to obtain mixture of 3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]prop-2-ene nitrile and 3-[2-cyclopropyl-4-(4-fluorophenyl)-quinoline-3-yl]-3-hydroxypropionitrile and the following addition of a dehydrating agent to the reaction mixture for carrying out dehydration. Under usual conditions new 3-[2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-yl]-3-hydroxyprionitrile is formed in the above said reaction as an intermediate compound. However, if the above said interaction reaction is carried out in organic solvent with dielectric permeability 10 or lower in the range of temperature from 20°C to 25°C then 3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-prop-2-ene nitrile is formed directly. 3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-prop-2-ene nitrile is used as the parent compound for synthesis of quinolyl propenal derivative that is used for synthesis of cholesterol-reducing agent. Invention provides simplifying method in preparing 3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-prop-2-ene nitrile.
EFFECT: improved preparing method.
18 cl, 7 ex
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