FIELD: medicine, biotechnology, genetic engineering, immunology. SUBSTANCE: invention can be used for immunization against human immunodeficiency virus type-1 (HIV-1) of subtype A. In recombinant plasmid DNA comprising gene gp120 of human immunodeficiency virus type-1 of subtype A in nucleotides sequences in codons with predominance of adenine and/or thymine adenine and/or thymine are substituted partially for guanine and/or cytosine. The prepared recombinant plasmid DNA provides expression of envelope protein of human immunodeficiency virus (HIV) type 1 of subtype A in cells of higher eucaryotic organisms. Invention provides carrying out human body immunization directly. EFFECT: valuable medicinal and biological properties of plasmid DNA. 3 dwg, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| RECOMBINANT PLASMID DNA PBMC-GAG(A)MOD FOR EXPRESSION OF HUMAN IMMUNODEFICIENCY VIRUS PROTEIN GAG IN EUCARYOTIC CELLS | 2003 |
|
RU2241752C1 |
| RECOMBINANT PLASMID DNA PBMC-RT(A)M-1 USED FOR EXPRESSION OF HUMAN IMMUNODEFICIENCY VIRUS REVERSE TRANSCRIPTASE (RT)IN HIGHER EUCARYOTIC CELLS | 2003 |
|
RU2238977C1 |
| RECOMBINANT PLASMID DNA pBMC-nef(A)m-1 EXPRESSING PROTEIN NEF OF HUMAN IMMUNODEFICIENCY VIRUS TYPE I VIRUS IN EUCARYOTIC CELLS | 2003 |
|
RU2229518C1 |
| pBMC-gp140(A)-hum EXPRESSION PLASMA DNA | 2006 |
|
RU2346044C2 |
| EXPRESSION PLASMID DNA pBMC - nef (A)-hum | 2006 |
|
RU2335540C1 |
| RECOMBINANT PLASMID DNA pBMC-RT(A)-hum FOR EXPRESSING PROTEIN OF REVERSE TRANSCRIPTASE OF HUMAN IMMUNODEFICIENCY VIRUS | 2006 |
|
RU2355764C2 |
| EXPRESSIVE PLASMID DNA p-BMC-gag (A)-HUM FOR EXPRESSION OF PROTEIN p55 HJV-1 IN EUKARYOTE CELLS | 2006 |
|
RU2345138C2 |
| POLYPEPTIDE E117 DESIGNED FOR ANTIBODY ASSAY TO THE HUMAN IMMUNODEFICIENCY VIRUS OF THE FIRST TYPE, DNA FRAGMENT HE117 ENCODING POLYPEPTIDE E117, RECOMBINANT PLASMID DNA PHE117 ENCODING POLYPEPTIDE E117, STRAIN OF BACTERIUM ESCHERICHIA COLI - A PRODUCER OF POLYPEPTIDE E117 | 1992 |
|
RU2043413C1 |
| CR3 CHIMERA GENE AND CR3 CHIMERA PROTEIN ENCODED THEREWITH (VARIANTS) INDUCING ANTI-HIV-1 IMMUNE RESPONSE | 2002 |
|
RU2302461C2 |
| RECOMBINANT PLASMID DNA PUE 41 ENCODING ENVELOPE PROTEIN FRAGMENTS GP 120 AND GP 41 OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, AND A STRAIN OF BACTERIUM ESCHERICHIA COLI-A PRODUCER OF ENVELOPE PROTEIN FRAGMENTS GP 120 AND GP 41 OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 | 1990 |
|
SU1766070A1 |
